Lab Updates

Introducing the ALEX2 Test

Lab Updates
Introducing the ALEX2 Test
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Introducing the ALEX 2 Allergy Test

Overview of Allergy Diagnosis

Allergy diagnosis involves:

  • Detailed history taking
  • Diagnostic tests: blood, skin prick, and/or provocation tests

Blood tests are divided into:

  • IgE-mediated
  • Non-IgE-mediated

IgE blood tests are safe and don’t require stopping medication beforehand.

What is ALEX 2?

The Allergy Xplorer (ALEX 2) is a multiplex IgE immunoassay using a chip-based macroarray:

  • Tests both whole allergen extracts and molecular components
  • Measures multiple allergens simultaneously
  • Cost-effective for complex cases and poly-sensitisation
  • Uses CCD inhibitor to reduce false positives from cross-reactivity
Groups of Allergens Tested with ALEX 2

Inhalants

  • Pollen
  • House dust & storage mites
  • Pets
  • Farm animals
  • Mould & yeast
  • Cockroach

Food Allergens

Plant-based

  • Nuts  (e.g. cashew, Brazil, pecan)
  • Legumes (e.g. peanut, soy, lentils)
  • Seeds (e.g. sesame, sunflower)
  • Cereals (e.g. wheat, oats, rice)
  • Spices (e.g. mustard, oregano)
  • Vegetables
  • Fruits

Animal-based

  • Milk (cow, goat, sheep, etc.)
  • Eggs
  • Meat

Seafood

  • Cod, crab, mussel, prawn, etc.

Edible Insects

  • Mealworms, crickets, locusts

Venoms

  • Ant, bee, wasp

Other

  • Latex
Interpretation of Results

You’ll receive a personalised, user-friendly report with:

  • Individual allergy profiles
  • Supporting information for clinical decisions
Conclusion

The ALEX 2 test replaces the ISAC test and enhances allergy diagnosis by:

  • Improving accuracy
  • Reducing costs
  • Supporting better treatment decisions

📞 Contact: NRL Immunology Lab – 012 678 0613/4
🌐 Website: ampath.co.za